Diisocyanate chemicals used to make polyurethane (e.g. coatings, foams) are well-known to cause asthma. The diisocyanate antibody (DiAb) test determines whether or not you have been exposed to diisocyanates. The test works by measuring the level of specific proteins of the immune system (antibodies) that recognize and bind to the diisocyanate chemical. Diisocyanate antibodies are not normally present in blood, but are triggered by exposure, which generally occurs in the workplace (diisocyanates are man-made chemicals, not found naturally). Thus, the presence of diisocyanate antibodies serves as a practical indicator of exposure. Most commonly, antibodies triggered by diisocyanate exposure are of the gamma isotype (IgG); however, in some individuals, exposure elicits diisocyanate antibodies of the epsilon isotype (IgE), which are typically associated with allergy and asthma. Diisocyanate antibodies of the IgE isotype, if present, correlate strongly with “diisocyanate asthma”, and thus serve as a indicator of the disease.

Click to download:
Diisocyanate Antibody (DiAb) Test Request Form (.pdf); (.doc)
Instructions for Sending Blood Samples (pdf); (.doc)
Sample Test Results (pdf); (.doc)

What is a diisocyanate antibody (DiAb) test?
How is a DiAb test done?
Who should have a DiAb test?
Will the DiAb test tell me if I have diisocyanate asthma?
Will the DiAb test tell me if I have been exposed to diisocyanates internally?
What do the values on the DiAb test results mean?
I have en elevated diisocyanate specific IgG titer, what does that mean?
I have an elevated diisocyanate specific IgE ratio, what does that mean?
Can I have a normal DiAb test and still have diisocyanate asthma?
Can I have a normal DiAb test despite internal exposure?
Will taking asthma medicine affect my test result?
How will my DiAb test results be used by my physician?
How do I get my test results?
Who else will see my test results?
How much does the test cost, will my insurance pay for the test?